ABSTRACT
The histopathology of the heart is described in an acute case of Chagas' disease (DC). Lesions involving the conducting system (SC) and the autonomic intracardiac nervous system (SNAIC) are emphasized. Light microscopy showed acute pan-carditis with plenty of Trypanosoma cruzi amastigotes within heart muscle cells. Multiple inflammatory foci were found in the SC with parasitic nests within the atrioventricular node and left his bundle. There were also severe atrial periganglionitis and perineuritis with or without peripheral involvement of those structures. Apparently there was no cardiac neuronal depopulation. The epidemiological study suggested transmission through Rhodnius pictipes. To the best of our knowledge, this is the first reported case of acute DC from the Amazonian basin with systematized microscopy study of the SC and SNAIC.
Subject(s)
Humans , Animals , Male , Child, Preschool , Heart/blood supply , Heart Conduction System/pathology , Chagas Cardiomyopathy/pathology , Autonomic Nervous System/pathology , Acute Disease , Brazil , Heart/parasitology , Fatal Outcome , Heart Conduction System/parasitology , Chagas Cardiomyopathy/parasitology , Myocardium/pathology , Autonomic Nervous System/parasitology , Trypanosoma cruzi/isolation & purificationABSTRACT
Este trabalho é uma descriçäo anatômica da drenagem venosa do coraçäo da cobaia. Observou-se, nesta espécie, que a drenagem venosa cardíaca é predominantemente confluente ao seio coronário. Este é continuaçäo direta da veia cardíaca magna, na cobaia. Todas as veias cardíacas e suas tributárias säo descritas. As disposiçöes anatômicas anatômicas das veias cardíacas säo comparadas e discutidas com outros dados, encontrados na literatura
Subject(s)
Guinea Pigs , Animals , Heart/blood supply , Drainage/veterinary , Guinea Pigs/anatomy & histology , Veins/anatomy & histologyABSTRACT
La participación de los Radicales libres (RL) en la génesis de los procesos isquémicos por reperfusión, ha adquirido amplia notoriedad en los últimos tiempos, habiendo, las recientes investigaciones, demostrado que, la reoxigenación del miocardio en hipoxia, determina un aumento de tejido lesionado. Existen evidencias que sugieren la participación de los RL, en forma total o parcial, en la producción de lesión microvascular de las células parenquimatosas en los tejidos isquemiados, a través del proceso hipoxia reoxiganación